Dermatological manifestations in Polycythemia Rubra Vera after long-term hydroxyurea therapy

Abstract

Hydroxyurea (HU) is an antitumor drug, chemically a derivative of hydroxylated urea. HU is used in the treatment of several hematological diseases and myeloproliferative disorders. With its prolonged use, various dermatological lesions are manifested by the patient, suggestive of toxic effects of hydroxyurea. Here, we reported a case of a 67-year-old lady with a diagnosis of Polycythemia Rubra Vera who presented with dermatological side effects after 13 years of primary treatment.